Asymmetric Total Synthesis of Bufospirostenin A

摘要：

　　The first and asymmetric total synthesis of bioactive bufospirostenin A,an unusual spirostanol with rearranged A/B rings,was accomplished.The synthetically challenging[5-7-6-5]tetracyclic ring system,found in bufospirostenin A and some other natural products,was efficiently constructed by the unique intramolecular rhodium-catalyzed Pauson-Khand reaction of an alkoxyallene-yne.The 11 stereocenters in the final product,including the 10 contiguous stereocenters,were installed diastereoselectively.

作者: Min-Jing Cheng Li-Ping Zhong Chen-Chen Gu Xu-Jiang Zhu Bo Chen Jun-Shan Liu Lei Wang Wen-Cai Ye Chuang-Chuang Li

作者单位: Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,Coll Shenzhen Grubbs Institute,Department of Chemistry,Southern University of Science and Technology,Shen School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,Coll

会议类型: 国际会议

会议名称: 第三届暨南大学粤港澳大湾区医学与健康发展分论坛——医学研究生学术论坛

会议地点: 广州

会议语种:英文

页码: 30-35

在线出版日期: 2020-11-28（万方平台首次上网日期，不代表论文的发表时间）