Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2

摘要：

　　Background The pneumonia caused by the 2019 novel coronavirus(SARS-CoV-2,also called 2019-nCoV)recently break out in Wuhan,China,and was named as CO VID-19.With the spread of the disease,similar cases have also been confirmed in other regions of China.We aimed to report the imaging and clinical characteristics of these patients infected with SARS-CoV-2 in Guangzhou,China.Methods All patients with laboratory-identified SARS-CoV-2 infection by real-time polymerase chain reaction(PCR)were col-lected between January 23,2020,and February 4,2020,in a designated hospital(Guangzhou Eighth People's Hospital).This analysis included 90 patients(39 men and 51 women;median age,50 years(age range,18-86 years).All the included SARS-CoV-2-infected patients underwent non-contrast enhanced chest computed tomography(CT).We analyzed the clinical characteristics of the patients,as well as the distribution characteristics,pattern,morphology,and accompanying manifestations of lung lesions.In addition,after 1-6 days(mean 3.5 days),follow-up chest CT images were evaluated to assess radiological evolution.Findings The majority of infected patients had a history of exposure in Wuhan or to infected patients and mostly presented with fever and cough.More than half of the patients presented bilateral,multifocal lung lesions,with peripheral distribution,and 53(59%)patients had more than two lobes involved.Of all included patients,COVID-19 pneumonia presented with ground glass opacities in 65(72%),consolidation in 12(13%),crazy paving pattern in 11(12%),interlobular thickening in 33(37%),adjacent pleura thickening in 50(56%),and linear opacities combined in 55(61%).Pleural effusion,pericardial effusion,and lymphade-nopathy were uncommon findings.In addition,baseline chest CT did not show any abnormalities in 21 patients(23%),but 3 patients presented bilateral ground glass opacities on the second CT after 3-4 days.Conclusion SARS-CoV-2 infection can be confirmed based on the patient's history,clinical manifestations,imaging character-istics,and laboratory tests.Chest CT examination plays an important role in the initial diagnosis of the novel coronavirus pneumonia.Multiple patchy ground glass opacities in bilateral multiple lobular with periphery distribution are typical chest CT imaging features of the COVID-19 pneumonia.

关键词： 2019 novel coronavirus pneumonia COVID-19 SARS-CoV-2 Infection Imaging features Computed tomography Ground glass opacification

作者: Xi Xu Chengcheng Yu Jing Qu Lieguang Zhang Songfeng Jiang Deyang Huang Bihua Chen Zhiping Zhang Wanhua Guan Zhoukun Ling Rui Jiang Tianli Hu Yan Ding Lin Lin Qingxin Gan Liangping Luo Xiaoping Tang Jinxin Liu

作者单位: Department of Medical Imaging Center,The First Affiliated Hospital,Jinan University,No.613,Huangpu R Department of Radiology,Guangzhou Eighth People's Hospital,Guangzhou Medical University,No.8,Huaying

会议类型: 国际会议

会议名称: 第三届暨南大学粤港澳大湾区医学与健康发展分论坛——医学研究生学术论坛

会议地点: 广州

会议语种:英文

页码: 113-118

在线出版日期: 2020-11-28（万方平台首次上网日期，不代表论文的发表时间）