Occurrence of neonicotinoid insecticides and their metabolites in tooth samples collected from south China:Associations with periodontitis
Neonicotinoid insecticides(NEOs)are widely used in agricultural production processes in China and worldwide.NEOs have been an increasing concern because of their potential toxicity to nontarget or-ganisms.However,studies that focused on human exposure to NEOs in China are limited.In this study,levels of six parent NEOs(p-NEOs),namely imidacloprid(IMI),acetamiprid(ACE),clothianidin(CLO),dinotefuran(DIN),thiamethoxam(THIX),and thiacloprid(THI),and three metabolites(m-NEOs),such as 5-hydroxy-imidacloprid(5-OH-IMI),1-methyl-3-(tetrahydro-3-furyl methyl)urea(UF),and N-des-methyl-acetamiprid(N-dm-ACE)were measured in 127 tooth samples collected from South China.P-NEOs and m-NEOs are frequently detected(76%-93%)in tooth samples,with median levels of 0.03-1.20 ng/g.UF is the most abundant NEOs in tooth samples(36%).Females have higher NEO levels than males,and gender-related differences in NEO levels are found.Associations among most p-NEOs are also found(p<0.05),indicating the source of human exposure to p-NEOs is related.However,no significant relationships(p>0.05)between levels of m-NEOs and their corresponding p-NEOs are found,suggesting that exogenous m-NEOs contribute to exposure.We have also examined the associations between hu-man NEOs exposure and periodontitis,and associations between NEO exposure and periodontitis are observed(OR=2.63-7.33;95%CI=1.01-21.1,p-trend<0.05).Our results suggest that NEO levels are associated with increased odds of prevalent periodontitis.This study is the first to report about p-NEOs and m-NEOs in tooth samples collected from South China.
Neonicotinoid insecticides Tooth Metabolites Periodontitis
Nan Zhang Bata Wang Zhanpeng Zhang Xufeng Chen Yue Huang Qihui Liu Hua Zhang
Department of Stomatology,First Affiliated Hospital,Jinan University,Guangzhou,510632,PR China Department of Orthopedics,First Affiliated Hospital,Jinan University,Guangzhou,510632,PR China Department of Dermatology,First Affiliated Hospital,Jinan University,Guangzhou,510632,PR China The Biomedical Translational Research Institute,Jinan University Faculty of Medical Science,Jinan Un
国际会议
第三届暨南大学粤港澳大湾区医学与健康发展分论坛——医学研究生学术论坛
广州
英文
210-217
2020-11-28（万方平台首次上网日期，不代表论文的发表时间）