Cyanidin-3-O-glucoside Protects Lens Epithelial Cells against High Glucose-Induced Apoptosis and Prevents Cataract Formation via Suppressing NF-κB Activation and Cox-2 Expression

摘要：

　　Diabetic cataract is one of the most important causes of blindness worldwide.Cyanidin-3-O-glucoside(C3G)is found to exert beneficial effects on many diabetic complications.However,its effect on diabetic cataract is not well known.Herein,we investigated the effect of C3G on high glucose-induced lens epithelial cell(SRA01/04)apoptosis and cataract formation as well as the involved mechanisms.We found C3G(20 μM)could preserve cell viability in SRA01/04 cells exposed to high glucose(100μM).Meanwhile,C3G inhibited SRA01/04 cell apoptosis and regulated the Bcl-2/Bax ratio.Additionally,C3G suppressed NF-κB activation and subsequent cyclooxygenases-2(Cox-2)expression,which are associated with the protection against apoptosis.Moreover,C3G attenuated lens opacity and protein aggregation in lens culture exposed to high glucose.In conclusion,C3G protected against high glucose-induced SRA01/04 cell apoptosis and cataract formation,which indicated the potential protection of anthocyanins on diabetic cataract.

关键词： anthocyanins cyanidin-3-O-β-glucoside lens epithelial cell apoptosis diabetic cataract high glucose

作者: Xi-Ling Song Mei-Jun Li Qun Liu Zi-Xuan Hu Zhi-Yi Xu Jia-Hui Li Wen-Lin Zheng Xiao-Mei Huang Fan Xiao Yu-Hong Cui Hong-Wei Pan

作者单位: Department of Public Health and Preventive Medicine,Jinan University,Guangzhou 510632,China Department of Ophthalmology,the First Affiliated Hospital,Jinan University,Guangzhou 510632,China Department of Histology and Embryology,School of Basic Medical Sciences,Guangzhou Medical University Department of Public Health and Preventive Medicine,Jinan University,Guangzhou 510632,China;West Cam Department of Histology and Embryology,School of Basic Medical Sciences and Guangzhou Institute of C Department of Ophthalmology,the First Affiliated Hospital and Institute of Ophthalmology,School of M

会议类型: 国际会议

会议名称: 第三届暨南大学粤港澳大湾区医学与健康发展分论坛——医学研究生学术论坛

会议地点: 广州

会议语种:英文

页码: 428-436

在线出版日期: 2020-11-28（万方平台首次上网日期，不代表论文的发表时间）