Urinary epidermal growth factor predicts renal prognosis in antineutrophil cytoplasmic antibody-associated vasculitis
Introduction The current study aimed to investigate the association between urinary epidermal growth factor (uEGF) and renal disease severity and outcomes in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV).Methods Intrarenal EGFmRNA expression was extracted from transcriptomic data of microdissected tubulointerstitial compartments of kidney biopsies of patients with AAV.uEGF was measured in 173 patients with AAV in active stage and 143 in remission,and normalised to urine creatinine excretion (uEGF/Cr).The association between uEGF/Cr (or EGFmRNA) and clinical-pathological parameters was tested using linear regression analysis.The ability of uEGF/Cr to predict renal outcomes was analysed using Coxs regression analysis.Results In patients with AAV,intrarenal EGFmRNA expression was significantly associated with estimated glomerular filtration rate (eGFR)(log2) at time of biopsy (β=0.63,p<0.001).The level of uEGF/Cr was significantly higher in gher risk of progression to composite outcome in patients with AAV.
Liang Wu Xiao-Qian Li Tanvi Goyal Sean Eddy Matthias Kretzler Wen-Jun Ju Min Chen Ming-Hui Zhao
Department of Medicine, Renal Division, Peking University First Hospital, Beijing, China;Institute o Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, Michigan Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, Michigan
国际会议
北京
英文
86-94
2019-03-30（万方平台首次上网日期，不代表论文的发表时间）