Cationic Cobalt(Ⅲ)-Catalyzed Aryl and Alkenyl C(c)H Amidation: A Mild Protocol for the Modification of Purine Derivatives

摘要：

　　A cationic cobalt(Ⅲ)-catalyzed direct C(c)H amidation of unactivated (hetero)arenes and alkenes by using 1,4,2-dioxazol-5-ones as the amidating reagent has been developed.This transformation proceeds efficiently under external oxidant-free conditions with a broad substrate scope.Moreover,6-arylpurine compounds,which often exhibit high potency in antimycobacterial,cytostatic,and anti-HCV activities,can be smoothly amidated,thus offering a mild protocol for their late stage functionalization.

作者: Yujie Liang Yu-Feng Liang Conghui Tang Yizhi Yuan Ning Jiao

作者单位: State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking Univer State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking Univer

会议类型: 国际会议

会议名称: 首都医学院校研究生学术论坛

会议地点: 北京

会议语种:英文

页码: 140-147

在线出版日期: 2019-03-30（万方平台首次上网日期，不代表论文的发表时间）