Application of Steroidal Bio-Biotransformation in the Pharmaceutical Industry
(0) Steroidal compounds have important physiological and pharmaceutical effects,and the market demand is huge.The steroidal compounds and their key steroids are prepared by microbial transformation,and are gradually applied to chemical synthesis methods with regional stereoselectivity,shortening synthesis steps,shortening production cycle,increasing yield and eco-friendliness.The catabolic mechanism needs to be further explored and determined.This paper summarizes the structure types and main sources of steroids,physiological functions,microbial transformation and catabolism mechanism,focusing on the key enzymes in the catabolism of steroids and their molecular mechanisms.Provide reference for the development of strains and the construction of engineering bacteria and the development of microbial transformation industrial production processes.
Terpenoids Microbial Transformation Side Chain Degradation Core Ring Degradation Metabolic Mechanism
Su Hailin
Yunnan College of Business Management,Yunnan,Kunming,650200,China
国际会议
西安
英文
78-83
2019-08-23（万方平台首次上网日期，不代表论文的发表时间）