Cerebral protection Effect of Danhong Injection on CPB Rats
Objective: to observe the influence of Danhong injection on cerebral infarction area and neuron apoptosis rate of rats undergoing cardiopulmonary bypass(CPB)and then discuss cerebral protection effect of Danhong injection.Method: 24 healthy and adult SD rats were divided into sham operation group,CPB group and medicine intervention group at random.Each group includes 8 rats.Cerebral infarction area and neuron apoptosis rate of 3 groups were compared.Results: compared with CPB group,cerebral infarction area of medicine intervention group decreased(P<0.05).Compared with sham operation group,OD value of apoptotic cells in CPB group rose significantly(P<0.01).Compared with CPB group,OD value of apoptotic cells in medicine intervention group reduced obviously(P<0.01).Bax level and Caspase-3 level of CPB group were obviously higher than that of sham operation group,while Bcl-2 was significantly lower than that of sham operation group(P<0.01).Bax level and Caspase-3 level of medicine intervention group was significantly lower than that of CPB group,while Bcl-2 was significantly higher than that of CPB group(P<0.01).Conclusion: Danhong injection can play a good cerebral protection role through lowering cerebral infarction area and neuron apoptosis rate.
Danhong injection CPB rat cerebral protection
Dezhan Li Shuang Han Tao Xie Man Li
Department of Anesthesiology,Jingzhou Central Hospital,The Second Clinical Medical College,Yangtze U Department of Gynaecology,Jingzhou Central Hospital,The Second Clinical Medical College,Yangtze Univ Department of Oncology,Jingzhou Central Hospital,The Second Clinical Medical College,Yangtze Univers
国际会议
南京
英文
181-185
2018-07-14（万方平台首次上网日期，不代表论文的发表时间）