A Comparative Study of Thermo-Sensitive Hydrogel with Water-insoluble Paclitaxel in Molecule, Nanocrystal and Microcrystal Dispersion

摘要：

　　Localized delivery of in situ thermo-sensitive hydrogel system may provide a long, steady and effective drug level inside of the tumor tissue.To clarify the effect of drug dispersion state and scale in such system on its outcome, we compared three types of thermo-sensitive hydrogel systems (Gel)with paclitaxel (PTX) or near infra-red probe DiR in molecules (MOs), nanocrystals (NCs) and microcrystals (MCs), respectively.It was demonstrated finally that the MOs-Gel release drug so fast, while MCs-Gel too slow, in vitro and in vivo.MCs-Gel is also unstable in terms of forming precipitate.NCs-Gel system, with moderate release ratio, results in the best tumor inhibition after introtumoral injection.

作者: Zhiqiang Lin Dong Mei Xianhui Chen Zhaoyang Wang Bing He Hua Zhang Xueqing Wang Wenbing Dai Qiang Zhang

作者单位: School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 12-14

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）