PEG-PE micelle based vaccine for treatment of HPV positive cervical carcinoma

摘要：

　　Successful delivery of tumor associated antigens (TAAs), such as peptides and proteins, to stimulate T cell immunity could improve vaccine strategies against tumor.Self-assembled PEG-PE micelle represents a novel and promising technology for the protection and delivery of tumor vaccine candidates to antigen-presenting cells (APCs).In our work, we applied self-assembly PEG-PE nanomicelle delivery system on therapeutic vaccine development for cancer treatment.The PEG-PE nanomicelle enhanced efficiently draining lymph nodes (DLNs) resident APCs targeting delivery for cross-priming of antitumor CTL response and demonstrated encouraging efficacy for both tumor control and memory protection.It harbors a great potential for clinical cancer treatment.

作者: Wei Lianq Chang Zhou Yan Qin Xiuli Wei Zihao Wang Luyao Wang

作者单位: Protein & Peptide Pharmaceutical Laboratory, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 29-33

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）