Polymerized Nucleic acids For Delivery and Targeting

摘要：

　　Long chain of polymerized nucleic acids with repeated sequences can be generated by rolling circle amplification (RCA).Polymerized DNA nucleic acids have been further processed for formulating DNA nanoballs for oligonucleotide delivery or for polyaptamer nanothreads as targeting moiety.First,biomimetic DNA nanoballs were designed for delivery of multiple antisense oligonucleotides (ASOs).Secondly, RCA was used to generate protein tyrosine kinase 7 (PTK7)-specific polyaptamer nanothreads as a targeting ligand of reduced graphene oxide (rGO) with doxorubicin.

作者: Mi-Gyeong Kim Joo Yeon Park Yu-Kyoung Oh

作者单位: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University,Seoul, 151-742, Republic of Korea

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 34-37

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）