Function Integration and Synchronization of Nanocarriers for Cancer Drug Delivery Cascade
The cancer drug delivery process is a cascade of five steps consisting of circulation in blood, accumulation and penetration into the tumor,cellular internalization and intracellular drug release,or the CAPIR cascade.Thus, the most challenging aspect of cancer nanomedicine design is the integration and synchronization of all functions required to accomplish the CAPIR cascade into one system, particularly, many of which are in opposite in different CAPIR steps.Here, we present a nanocarrier likened to a cluster bomb capable of releasing small pH-sensitive drug-carrying nanoparticles (bomblets).This cluster bomb-like nanocarrier synchronizes pegylation-to-depegylation,large-to-small size, and neutral-to-positive charge transitions essential for accomplishing the CAPIR cascade, enabling the carried drug to reach cells deep in the tumor and circumvent the drug resistance,significantly enhancing its in vivo antitumor efficacy.
Youqing Shen Xuanrong Sun Jianbin Tang Xiangrui Liu
Center for Bionanoengineering and State Key Laboratory of Chemical Engineering Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China 310027
国际会议
沈阳
英文
39-41
2016-04-28（万方平台首次上网日期，不代表论文的发表时间）