High-throughput measurement of drug-cyclodextrins interactions

摘要：

　　A high-throughput method measuring drug-cyclodextrins (CDs) interactions in real time and label free manner was developed and presented in this report.Herein, we conjugated small molecule microarray (SMMs) with label free surface plasmon resonance imaging (SPRi) for the measurement of kinetic parameters for drug-cyclodextrins interactions in high-throughput manner.In total, 450 FDA approved drugs were immobilized onto biosensor surface by using photo-cross-linked technique and kinetics against 5 types of cyclodextrins were measured.

作者: Vikramjeet Singh Yaping He Jianghui Xu Parbeen Singh Jiwen Zhang

作者单位: Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 92-95

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）