Bioavailability improvement strategies of poorly water-soluble drugs based on supersaturation mechanism: an update
(0) The formulation development for poorly soluble drugs is still remaining a challenge.Supersaturating drug delivery systems (SDDS) or drug delivery systems based on supersaturating provide a promising way to improve the oral bioavailability of the poorly water-soluble drugs.In supersaturable formulations,drug concentration exceeds the equilibrium solubility when exposed to the gastrointestinal fluids and the supersaturation state maintains long enough to be absorbed, resulting in compromised bioavailability.In this article, the mechanism of the generating and maintaining of the supersaturation and the evaluation methods of supersaturation assays are discussed.Recent advances of different drug delivery systems based on supersaturating are focuses on and discussed in detail.
Meiyan Yang Wei Gong Yuli Wang Li Shan Ying Li Chunsheng Gao
State key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
国际会议
沈阳
英文
96-100
2016-04-28（万方平台首次上网日期，不代表论文的发表时间）