Dual functional LipoMETs with fusogenic and apoptotic properties mediate envelope-type nanoparticles to combinational oncogene silencing

摘要：

　　We herein report on a liposomal derivative of metformin, i.e.LipoMET, which is hypothesized to take advantage of intrinsic tumor apoptosis ability of biguanide moiety as well as a fusogenic gene vehicle to achieve the combinational antitumor effects.Systemic administration of VEGF siRNA loaded targeted LipoMETPH NPs significantly down-regulated the expression of oncogene VEGF in the NCI-H460 xenograft tumor and induced ~21% tumor cell apoptosis in vivo.In comparison with common cationic control group of LipoEDAPH NPs,LipoMETPH NPs carrying siRNA led to dramatic inhibition of tumor growth, with little in vivo toxicity.

作者: Kai Shi Leaf Huang

作者单位: Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016 Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Ch

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 101-103

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）