Formulation and Evaluation of Microemulsions Containing BSA as a Model Antigen

摘要：

　　Stable microemulsion adjuvant containing vegetable oil, nonionic surfactants and/or cationic surfactant has been developed and sterilized by autoclaving.Protein integrity study demonstrated that microemulsion compositions had no any influence on both primary and secondary structures.Moreover, in vitro cellular uptake study on human monocyte /macrophage cell line showed that the uptake of FITC-BSA-loaded microemulsions significantly increased (p-value < 0.05) when compared with those in PBS and AddaVaxTM.Based on these preliminary results, it was concluded that the prepared microemulsion formulations could be used as novel adjuvants for various vaccines.

作者: Sakalanunt Lamaisakul Angkana Tantituvanont Vimolmas Lipipun Garnpimol C.Ritthidej

作者单位: Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences,Chulalongkorn University, Bangkok 10330, Thailand

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 110-112

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）