Dual Thermo/Oxidation-responsive Polymeric micelles: Characterization, Morphology Transformation and Triggered Drug Delivery
The successful synthesis of novel amphiphilic poly(propylene sulphide) (PPS) and poly(N-isopropylacrylamide) (PNIP AM) block copolymers is reported as a strategy to respond stimuli in inflammatory tissues.In addition to the formation of defined PPS-block-PNIPAM assemblies,the encapsulation of fluorescent dyes and the selective response to the heat and oxidants are studied.The synthesis of the dual responsive PPS-(b)-PNIPAM is carried out by combining a living anionic ring-opening and an atom transfer radical polymerization (ATRP) process.The resulting copolymers are self-assembled in water to form micellar structures, which are characterized by dynamic light scattering (DLS), atom forced microscopy (AFM).DLS measurements show that heat and oxidants cause a significant change to the hydrodynamic diameter of the micelles.Flu orescent spectroscopy data confirm the liberation of the encapsulated dye, which indicates the decomposition of the micelles and validates the concept of stimudi-triggered payload release.Finally,cytotoxicity assays confirm that the PPS-(b)-PNIPAM micelles are biocompatible with A549 lung cancer cells.
Meiqiong Tang Qiang Zheng Gu Jin Ping Hu Yun He
College of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University, 55 South Daxuecheng Road, Chongqing 401331, China
国际会议
沈阳
英文
115-117
2016-04-28（万方平台首次上网日期，不代表论文的发表时间）