Zero-order release of highly water-soluble metoprolol succinate from EC/drug-coated pellets

摘要：

　　Usually, the release of the water soluble drug from ethylcellulose (EC)-coated pellets shows an initial lag phase (slow/non drug release phase).We attempted to use model drug metoprolol succinate (MS) as a pore former in the EC-coating film to eliminate the lag phase.Interestingly, the overall in vitro and in vivo drug release rates from EC/MS and EC/HPC-coated pellets were comparable.However,the initial lag phase associated with EC/HPC coating was not observed from EC/MS-coated pellets, which was further confirmed by in vivo drug release in beagle dogs.Moreover, this novel coating strategy also can significantly reduce the pellets sticking and enhance the coating efficiency, which suggests that it is very valuable for the advancement of sustained-release pellets.

作者: YuLi Wang MeiYan Yang Shuai Shao Li Shan Wei Gong ChunSheng Gao

作者单位: State key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 125-127

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）