Molecular interaction between drug-excipient and its implication on the formulation design of poorly water soluble drugs
(0) With the extensive implementation of combinatorial chemistry and high throughput screening by the pharmaceutical industry, a large percentage (＞50％) of identified drug development candidates are poorly water-soluble, which presents a critical hurdle for the pre-clinical and clinical assessments, as well as commercial drug product development.In many conventional solid dosage forms, drug molecules often exists as crystalline particles in the formulation thus drug-excipient interactions are often neglect-able, and the dissolution seldom generate solution supersaturation.While in many alternative formulations for solubilize enhancement, such as drug-polymer solid dispersions, solubilized capsules, etc.,drug disperses within the excipients as amorphous, molecular forms, and solution supersaturation is often observed once these formulations meet aqueous medium.
Feng Qian
Tsinghua University, Beijing, China
国际会议
沈阳
英文
143-144
2016-04-28（万方平台首次上网日期，不代表论文的发表时间）