Pulmonary Delivery of Peptide Drug Using Surface-modified Liposomes to Improve Systemic Absorption

摘要：

We have investigated surface-modified liposomes (100-200 nm) for pulmonary delivery of a peptide drug.Chitosan oligosaccharide (oligoCS),polyvinyl alcohol with a hydrophobic anchor (PVA-R)or carbopol-wheat germ agglutinin conjugate (CP-WGA) were examined as surface modifiers.The effect of liposomal surface modification on the behavior of the liposomes on pulmonary administration were evaluated in vitro and in vivo.

作者: Kohei Tahara Mitsutaka Murata Risako Onodera Hirofumi Takeuchi

作者单位: Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, Gifu, 501-1196, Japan

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 149-151

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）