Study on curcumin and polycurcumin nanoparticles for tumor treatment
We herein report on our recent research results about curcumin and polycurcumin nanoaprticles for tumor treatment.Curcumin is a diarylheptanoid, the principal curcuminoid of turmeric, which can inhibit the proliferation of different types of cancer, such as lung cancer,breast cancer, colon cancer and prostate cancer.Especially, curcumin is also a chemosensitizer and can reverse tumor multidrug resistance.Although curcumin has good in vitro antitumor effect, its in vivo activity is poor, this is because curcumin is almost water-insoluble and instable at physiological pH, its biological half-time is less than 10 mins.We synthesized two types of biodegradable amphiphilic icpoly(anhydride-ester)-b-poly(ethylene glycol):PAE-b-4-armPEG and PAE-b-PEG, made them self-assemble into micelles as curcumin nanocarriers.We further investigated thire curcumin loaded micelles and found that they have better antitumor effects than free curcumin.
Li Lv Fangzhou Li Zhipeng Zhang Jining Wang Yuanyuan Shen Shengrong Guo
School of Pharmacy, shanghai Jiao Tong University, Shanghai, 200240, China
国际会议
沈阳
英文
152-153
2016-04-28(万方平台首次上网日期,不代表论文的发表时间)