Rheology in Continuous Manufacturing of Future Pharmaceuticals:Understanding the Interactions and Flow Behavior of Drug-Polymer Mixtures in Hot Melt Extrusion and Fused Deposition Modeling

摘要：

　　Rheology is a study of flow and deformation of matter, especially of fluids that have complex,non-Newtonian flow behavior.Such flow is encountered in manufacturing of dosage forms from mixtures of drug(s) and thermoplastic polymer excipients, using methods based on melt processing,such as hot-melt extrusion (HME) and three dimensional (3D) printing by fused deposition modeling (FDM) principle.This work shows some examples of utilizing rheological methods in characterization of drug-polymer mixtures and in evaluation of suitable process in conditions in HME and FDM.

作者: J.Aho L.Arnfast J.P.Botker S.Baldursdottir J.Rantanen

作者单位: University of Copenhagen, Department of Pharmacy, 2100 Copenhagen, Denmark

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 157-159

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）