Complexed vesicular phospholipid gels loaded with cytarabine: antitumor efficacy against glioma
(0) The purpose of this study was to develop polyelectrolyte complexed vesicular phospholipid gels (VPGs) loaded with cytarabine (Ara-C) that enhance in vitro and in vivo anti-glioma effects.Complexation of charged VPGs with polyelectrolyte (ε-polylysine and T-polyglutamic acid) was developed by electrostatic interactions.The TEM images and physicochemical properties of polyelectrolyte complexed VPGs verified polyelectrolyte covered on the vesicular surface.Specially, compared with ε-polylysine complexed VPGs (PLL-SCS VPGs), y-polyglutamic acid complexed VPGs (PGA-ODA VPGs)demonstrated higher in vitro cytotoxicity and cellular uptake efficiency in U87-MG glioma cells,and a single dose of Ara-C loaded PGA-ODA VPGs exhibited significant in vivo antitumor effects at least 32 days.The results were speculated that there might be γ-PGA specific receptors on the surface of cancer cells.In conclusion, complexation of charged VPGs with γ-PGA is a promising delivery depot for the treatment of glioma.
Na Qi Cuifang Cai Yu Zhang Xing Tang
Department of Pharmaceutics,Guilin Medical University, Guilin, 541004, PR China Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, 110016, PR China
国际会议
沈阳
英文
179-180
2016-04-28（万方平台首次上网日期，不代表论文的发表时间）