Acid-Activatable Nanoparticles for Combating Drug Resistant Cancer

摘要：

　　In this report, we presented novel acid-activatable polymeric nanoparticles for combating multidrug resistance in breast cancer.The nanoparticles displayed silenced fluorescence during the blood circulation, while activated at weakly acid condition in the endocytic vesicles to induce fluorescence signal for fluorescence imaging.Upon near infrared (NIR) laser irradiation,the micelle generated reactive oxygen species (ROS) to trigger cytosol release of the chemotherapeutics and perform photodynamic therapy (PDT).This robust nanoplatform reported in this study might provide a novel insight for designing novel drug delivery systems for therapy of drug resistant cancer.

作者: Haijun Yu Tingting Wang Dangge Wang Jianping Liu Zhiwen Zhang Yaping Li

作者单位: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P.R.China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 183-185

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）