Pharmacokinetic Study of TCPLs Optimized and Developed by Central Composite Design
Tilianin is attracting considerable attention because of its antihypertensive, anti-atherogenic and anticonvulsive efficacy.However, tilianin has poor oral bioavailability.Thus, to improve the oral bioavailability of tilianin, composite phospholipid liposomes were adopted in this work as a novel nanoformulation.Results indicated these variables were the major contributing variables for particle size (101.4 ± 6.1 nm), higher EE (90.28% ± 1.36%), zeta potential (-18.3 ± 2.6 mV) and PDI (0.122 ± 0.027).Subsequently, pharmacokinetic results demonstrated that the Cmax of TCPLs became 5.7 times higher than that of tilianin solution and that the area under curve of TCPLs became about 4.6-fold higher than that of tilianin solution.Overall, our results suggested that the prepared tilianin composite phospholipid liposome formulations could be used to improve the bioavailability of tilianin after oral administration.
Cheng Zeng Chenghui He Meie Tan Xiaoyi Yang Wei Huang Jianguo Xing
Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830054, P.R.China;Dep Department of Pharmaceutics, Xinjiang Institute of Materia Medica, Urumuqi 830004, P.R.China Department of Pharmaceutics, Xinjiang Institute of Materia Medica, Urumuqi 830004, P.R.China;State K State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of
国际会议
沈阳
英文
186-188
2016-04-28（万方平台首次上网日期，不代表论文的发表时间）