Integrity Monitoring of mPEG-PLGA Nanopartricles in MDCK Cells and Larval Zebrafish Revealed by Fluorescence Resonance Energy Transfer

摘要：

Polymeric nanoparticles have been extensively for oral drug delivery.However,translation of polymeric nanoparticles from the laboratory to the clinic is limited by a poor understanding of their in vitro and in vivo fate following administration.In particular, the intracellular integrity and in vivo stability are still uncertain.The purpose of this work was to monitor the integrity of mPEG-PLGA nanoparticles in MDCK cells and larval zebrafish models by using fluorescence resonance energy transfer (FRET).

作者: Tongkai Chen Ye Li Xiang Yi Simon Ming-Yuen Lee Ying Zheng

作者单位: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina C

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 189-189

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）