Highly water-soluble metoprolol tartrate-loaded sustained-release pellets with talc as anti-adherent in layering and coating process: Formulation and in vitro evaluation
A major problem encountered in formulation highly water-soluble drugs into coated pellets is the sticking of the layered or coated substrates.In the present study, highly water-soluble metoprolol tartrate (MT)-loaded Eudragit NE 30 D-coated sustained-release (SR) pellets were prepared using talc simultaneously as an anti-adherent in layering and coating process.Talc significantly reduced the stickiness of the layered or coated substrates during the layering or coating process, thus enhancing the process smoothness.Meanwhile, the levels of talc incorporated into film coating formulations influenced the release properties of coated pellets.The drug release rate in the initial stage (within 2 hours) increased with increasing levels of talc in coating dispersions.However,subsequently swelling of membrane and expanding of the copolymer network eliminated the influence of talc and the drug release was controlled by polymeric membrane.The results of present study suggested that talc in layering solution and coating dispersions contributed to reducing sticking of layering or coating substrates, facilitating the layering or coating process as well as the release properties.
Wei Gong YuLi Wang MeiYan Yang Ruifang Shen Shuai Shao Li Shan ChunSheng Gao
State key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
国际会议
沈阳
英文
190-192
2016-04-28（万方平台首次上网日期，不代表论文的发表时间）