Optimization and preparation of cRGDyK mediated pH-sensitive paclitaxel liposomes using box-Behnken design method and its antitumor activities

摘要：

　　The formulation of cRGDyK mediated pH-sensitive paclitaxel liposomes was optimized using Box-Behnken design.Results showed that the optimal conditions were: the optimal phospholipids concentration was 17.49 mg/mL,phospholipids to cholesterol ratio was3.87∶1,drug-to-lipid ratio was 8.0∶1, respectively.In the in vitro release assay, cRPSLP/PTX showed significant pH-sensitive feature and sustained release behavior.In the MTT assay, cRPSLP/PTX could dramatically increase cytotoxicity against HepG2 cell due to receptor medicated endocytosis and pH-responsive drug release.This study shows that the Box-Behnken design method could be used to optimize the prescription cRPSLP/PTX.

作者: Jiulong Zhang Dawei Chen Xiuli Zhao

作者单位: Department of Pharmaceutics, School of pharmacy, Shenyang pharmaceutical University.Shenyang,110016, China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 203-205

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）