Anti-tumor effects of chitosan-based non-viral siRNA delivery system

摘要：

　　We aimed to establish a new type of non-viral vector based on chitosan to delivery siRNA efficiently.In this paper, we synthesized 6R-g-CS and prepared siRNA loaded 6R-g-CS nanoparticles through complex coacervation method.The functional siRNASur was delivered to treat breast cancer, and we conducted anti-proliferation assay and apoptosis assay to investigate the anti-cancer effect of6R-g-CS/siRNASur.

作者: Zheming Zhang Feifei Yang Wei Huang Zhonggao Gao Liqing Chen Qiming Wang Mingji Jin

作者单位: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R.China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 206-207

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）