SynB3-functionalized Nanodiamond for the Enhanced Brain Delivery of Endomorphin-1

摘要：

　　Use of nanodiamonds is a promising strategy for overcoming the blood-brain barrier and delivering drugs to the brain.In this study, the therapeutic endomorphin-1, an endogenous μ-opioid but unable to penetrate blood-brain barrier, was conjugated to the surface of SynB3-functionalized nanodiamonds by physical adsorption and chemical connection in order to premature release and improve its pharmacological effect.The results showed that cell penetrating peptides functionalized nanodiamonds strategies could enhance brain uptake of endomorphin-1 and more importantly, the two methods are different on the release of the drug due to the different connection.

作者: Hui Liu Xiaoning Zhao Jingman Ni

作者单位: School of Pharmacy, Lanzhou University, Lanzhou, Gansu, 730000, P.R.China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 215-217

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）