Effects of statin-loaded fibrous mats on eNOS/NO and angiogenesis during diabetic skin wound healing

摘要：

　　Statin-loaded polymeric fibrous mats were prepared by electrospinning and applied in the culture of vascular endothelial cells in high-glucose condition and in the rat model of diabetic skin ulcer.Results show that the statin-loaded mats relieved the high-glucose induced decrease in cell viability and promoted nitric oxide (NO) synthesis, in vitro.In a rat model of diabetes, the statin-loaded mats promoted endothelial nitrix oxide (eNOS) expression and NO synthesis in/around the regenerated tissues,accelerated vascularization, elevated blood supply,and promoted the skin wound healing.

作者: Ye Yang Dengke Yin

作者单位: School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 220-222

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）