A peptide-tethered scaffold promotes spinal cord recovery by synergism with mesenchymal stem cells
(0) Neural tissue regeneration after spinal cord injury is among the most challenging issues due to the loss of neurons and secondary complications after spinal cord injury.Implantation of stem cells and biomaterial scaffolds has been proven to be an effective way to replace the lost neurons and bridge the nerve tissues.In this study, a hyaluronic hydrogel scaffold was modified with the adhesive peptide PPFLMLLKGSTR.Rat bone marrow mesenchymal stem cells (MSCs) was encapsulated into the scaffold to form a composite implant for nerve tissue repair after spinal cord transection.Peptide modification significantly promoted the cell adhesion and improved cell viability in vitro.The implant of scaffold with MSCs exhibited better performance in MSC survival and nerve tissue recovery than that of scaffold or MSCs only.The implant consist of the peptide modified scaffold and MSCs provides integrated effects to overcome the complications of spinal cord injury.
Liming Li Min Han Jianqing Gao
Zhejiang Province Key Laboratory of Anti-Cancer Research, College of Pharmaceutical Sciences,Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, Zhejiang, Peoples Republic of China
国际会议
沈阳
英文
225-226
2016-04-28（万方平台首次上网日期，不代表论文的发表时间）