Development and characterization of the TFDM-SLNs for oral delivery

摘要：

　　To improve the solubility and the bioavailability of total flavonoids from Dracocephalum moldavica L.(TFDM), TFDM loaded solid lipid nanoparticles (SLNs) were prepared.The stability of TFDM-SLNs was investigated.The optimized formulation of TFDM-SLNs was in spherical shape, similar in size with the mean particle diameter at (141.85±0.24 nm), (PDI) (0.21±0.97) and zeta potential of (-28.7±1.94mV),respectively.The average EE was 98.07±0.87% and the DL was 8.61±1.27%.The method of high shear homogenize followed ultrasonic is suitable for TFDM-SLNs preparation.

作者: Meie Tan Cheng Zeng Jianguo Xing

作者单位: Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, 830001, China Xinjiang Institute of Materia Medica, Urumqi, Xinjiang Uygur Autonomous Region, 830001, China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 243-245

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）