PEGylated liposomes of homoharringtonine for antileukemic therapy: safety and pharmacokinetic evaluation
To improve the safety and efficiency,long-circulating liposomes containing Homoharringtonine (HHT) (LCLipo-HHT) were developed, and their chemical and physicochemical properties were evaluated.LCLipo-HHT presented adequate properties,including a mean diameter of 75.6 ± 3.2 nm, and a zeta potential of 16.9 ± 2.5 mV.LCLipo-HHT has shown much better safety than HHT solution in the elementary toxicity experiments.The increased plasma concentration as well as blood circulation time were observed after surface modification of the PEG2000 to distearoyl phosphoethanolamine (DSPE), which may enhance the pharmacological activity of HHT to promote drug efficiency.Therefore, the results of the present work suggest the applicability of LCLipo-HHT as a new and promising anticancer formulation for antileukemic therapy.
Dong Liu Fang Yang Fei Xiong Ning Gu
State Key Laboratory of Bioelectronics and Jiangsu Key Laboratory for Biomaterials and Devices,School of Biological Science & Medical Engineering, Southeast University, Nanjing, 210096, Peoples Republic of China
国际会议
沈阳
英文
250-251
2016-04-28（万方平台首次上网日期，不代表论文的发表时间）