Poly(lactide-co-glycolide) Coated Hydroxyapatite Microspheres for Prolonged Doxycycline Release after Periodontal Pocket Administration

摘要：

　　Doxycycline (DOXY) loaded inorganic/organic hybrid microspheres composed of hydroxyapatite (HAP) microspheres and poly (lactic-co-glyeolic acid) (PLGA) shell coating was fabricated for sustained release as reported in previous studies.Recently, the in vivo release of DOXY from the hybrid microspheres was evaluated after administration in the periodontal pockets of rabbits.The present results indicated that drug levels in the gingival crevicular fluid (GCF) could be maintained above the effective inhibiting concentration (MIC) for over 7 days for both naked HAP microspheres (HAP-DOXY) and PLGA coated HAP microspheres (PLGA-HAP-DOXY), while the burst release of DOXY from PLGA-HAP-DOXY was significantly lower.The study showed great potential applications of the drug loaded PLGA-HAP microspheres for the treatment of various periodontal diseases.

作者: Z.Shi Y.-J.Bai R.-X.Wang S.-N.Wang H Xu

作者单位: School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016 Department of Dentistry, The Peoples Hospital of Liaoning Province, Shenyang 110016, China School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 254-255

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）