Studies on a solid-in-oil nanosuspension to improve the oral absorption of risedronate sodium (Ⅰ): in vitro and in vivo evaluations

摘要：

　　The aim of this work was to examine the usefulness of a solid-in-oil nanosuspension (SONS)to improve the oral absorption of risedronate sodium (risedronare) by means of in vitro and in vivo evaluations in rats.From the results obtained,the SONSMCT which exhibited risedronate release was dependent on the lipase degradation of medium-chain triglycerides (MCT), the oil phase,and produced the greatest increase in the oral absorption of residronate.From comparisons of the in vivo data with/without co-administration of Ca2+,a precipitation reagent used to inhibit drug uptake in an aqueous medium, it was found that the drug-surfactant complexes acted as a mucosal delivery carrier to protect risedronate from forming non-absorbable complexes with Ca2+.

作者: Yanting Hou Yuanfang Tian Yaxuan Liu Hongze Piao Fude Cui Hongyu Piao

作者单位: Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, No.103,Wenhua Road, Shenyang 110016, China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 258-259

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）