Self-Assembled Nanosystem of Disulfide Bond Inserted Prodrugs for Paclitaxel Delivery

摘要：

　　A novel disulfide bond linked oleate prodrug of paclitaxel (PTX-S-S-OA) was designed to facilitate the rapid and differential drug release from the hydrophobic conjugates of PTX.Ester bond linked conjugate (PTX-OA) was synthesized as the non-sensitive control.these hydrophobic prodrugs could self-assembly into nanoparticles (NPs) with uniform particle size (100 nm) and high drug-loading efficiency (over 50%, w/w).PEGylated NPs of PTX-S-S-OA showed rapid and differential release of PTX triggered by redox stimulus, resulting in significantly enhanced in vitro cytotoxicity.Such a prodrug-based nanoplatform has potential to be used as promising nanomedicine in cancer therapy.

作者: Cong Luo Bingjun Sun Jin Sun Zhonggui He

作者单位: Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 260-262

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）