Interfacial molecular interactions between the insoluble antitumor drug AD-1 and DSPC
(0) In this study, molecular interactions between the anti-cancer agent 25-methoxydammarane-3b,12b,20-triol (AD-1)and phospholipid DSPC were investigated using the Langmuir film balance technique.In addition,the drug-DSPC binary supramolecular structure was also deposited on the mica plates as shown by atomic force microscopy (AFM).Finally,molecular docking calculations explained satisfactorily that, based on the conformations interactions (conformation recognition), even at an AD-1/DSPC molar ratio as high as 8:2, the interfacial stabilization of the AD-1/DSPC system was fairly strong due to hydrophobic interactions.A higher loading capacity of DSPC might be possible, as it is associated with a more flexible geometrical environment, which allows these suprarnolecular structures to accept larger increases in drug loading upon steric binding.
Tian Yin Haibing He Yu Zhang Xing Tang
School of Functional food and Wine, Shenyang Pharmaceutical University, Shen Yang, 110016,China School of Pharmacy, Shenyang Pharmaceutical University, Shen Yang, 110016, China
国际会议
沈阳
英文
267-268
2016-04-28（万方平台首次上网日期，不代表论文的发表时间）