Synthesis and anti-tumor activity in vitro of Indomethacin-PEG-1500 ester
New ester prodrug of indomethacin-poly (ethylene glycol) (PEG) was designed, synthesized and evaluated with the aim of improving the solubility and retard the adverse effects of gastrointestinal origin.The carboxyl in indomethacin is reacted with hydroxyl group of PEG to form the carboxyester of the prodrug.The structure of indomethacin-PEG-1500 ester was confirmed by means of UV, IR, 1H-NMR and HPLC.The inhibitory ratio of indomethacin-PEG-1500 ester is comparative to that of free indomethacin.In vitro determination of the growth inhibitory activity of the indomethacin-PEG-1500 ester using the MTT colorimetric assay revealed mean maximum toxicity of 46.01%.
Lei Chen Shuang Guo Feifei Bai Xiahui wang Yue Li Jing Wang Xiangrong Zhang
School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016,China School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, 103 Wenhua Road, Sh School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, S
国际会议
沈阳
英文
269-270
2016-04-28（万方平台首次上网日期，不代表论文的发表时间）