Effect of the chemically substituted L-histidine on the physio-chemical properties of Poly(L-histidine) based micelles

摘要：

　　Triblock copolymer of poly(ethylene glycol)-poly(d,l-lactide)-poly(2,4-dinitrophenol-l-histidine)(mPEG-b-PLA-b-DNP-PHis) with DNP group substituted to the saturated nitrogen of l-histidine were synthesized.The pH sensitive properties of the copolymer micelles were characterized using an acid-base titration method,fluorescene probe technique, DLS observation and in vitro drug release, respectively.The results suggest that mPEG-b-PLA-b-DNP-PHis copolymers showed increased particle size, and similar pH responsive properties with mPEG-b-PLA-b-PHis copolymers.These results suggest that saturated nitrogen of PHis may serve as a valuable site for chemical modification of the PHis based copolymers because of the little effect on the pH responsive properties.However, selection of the substitution group needs to be considered due to the possible increase of micellar particle size of the micelles, leading to compromised passive targeting..

作者: Mingxi Qiao Xiaojun Zhang Dawei Chen

作者单位: School of Pharmacy, Shenyang Pharmaceutical University, P.O.Box 42, Wenhua Road 103, Shenyang,Liaoning Province 110016, PR China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 273-275

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）