Co-delivery of cytostatics and siRNA: synergistic therapy to cancer cells

摘要：

　　The aim of this study was to design a long-circulating drug delivery system with siRNA and a water-insoluble chemotherapeutic drug, paclitaxel (PTX), to enhance encapsulation of GAPDH-siRNA and therapeutic efficacy of PTX by using Nano liposome technology.Liposomes were prepared by asymmetric reverse-emulsion evaporation method.The transfection efficiencies of formulations were expressed by GAPDH Enzyme Activity tests.We showed clearly synergistic suppression of GAPDH-siRNA with PTX to tumor cells in hypoxia culture environment.In allusion to the resistant cells living at hypoxia part in the tumor, this is an appropriate treatment to improve the efficiency of chemotherapy drug.

作者: Jibin Guan Enrico Mastrobattista Gert Storm Jin Sun Zhonggui He

作者单位: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China;Departments of Pharma Departments of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences,Faculty of science, Utre School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 284-285

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）