The influence of PEG on the TAM targeting of SA-modified liposomes
Our previous study showed that sialic acid derivative (SA-ODA) modified pixantrone (Pix)liposomes obtained a good tumor treatment effect by targeting tumor-associated macrophage (TAM).To explore whether a longer circulation time can further enhance the targeting efficiency of SA-modified liposomes, we synthesized a PEGylated SA derivative of SA-PEG2000-DSPE, and constructed a long-circulating targeting liposomes with Pix loaded inside.The SA-PEG2000-DSPE modified liposomes was nano-scaled (102.2 ±2.2 nm) with an encapsulation efficiency of 98.3% ±0.6%.The pharmacodynamic results showed that the antitumor effect of SA-PEG2000-DSPE modified liposomes was weaker than that of SA-ODA modified liposomes, and the survival time of the mice treated with SA-PEG2000-DSPE modified liposomes also was shorter than that of SA-ODA modified liposomes.Therefore, a long-circulation time cant enhance the TAM targeting efficacy of SA-modified liposomes.
Yanzhi song Zhennan She Lei Shang Liang li Xinrong Liu Yihui Deng
Shenyang Pharmaceutical University, Shenyang 110016, China Yunnan Baiyao Group Co., Ltd,Kunming, 650500, China China Medical University, Shenyang, 110001, China
国际会议
沈阳
英文
288-289
2016-04-28（万方平台首次上网日期，不代表论文的发表时间）