Optimization on the preparation of Anethol Trithione ophthalmic nanoemulsion coated with chitosan using central composite design-response surface methodology

摘要：

　　The Anethol Trithione ophthalmic nanoemulsion was prepared by ultrasonic cell grinder.To optimize the preparation of Anethol Trithione ophthalmic nanoemulsion coated with chitosan, we used the central composite design response surface methodolody (RSM-CDD).In the RSM-CCD, mean diameter and Zeta potential were selected as response variables, however, RH40, EPC and chitosan were employed as independent variables.The mean diameter and Zeta potential of the optimal preparation were (201.1 ± 0.9) nm and (21.22 ± 0.86) mV.The deviations between measured values and predicted values were not considerable.The model established by the RSM-CCD method can be rational for optimization of the preparation of Anethol Trithione ophthalmic nanoemulsion.

作者: Jing Sun Yanzhi Song Xiangyun Lin Mei Lu Songlei Zhou Yang Liu Lirong Wang Chunxiu Liu Mengjing Wang Yihui Deng

作者单位: College of Pharmacy, Shenyang Pharmaceutical University,Shenyang 110016, P.R.China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 293-295

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）