Beagle is a Better Animal Model for the Study of the ABC Phenomenon Induced by Conventional Emulsion

摘要：

　　Three different animal models (mice, rats and beagles) were used to study the accelerated blood clearance (ABC) phenomenon induced by conventional emulsion (CE).Results showed that CE could not induce the ABC phenomenon at different doses and in different time intervals between injection in mice and rats.However, CE could cause the ABC phenomenon in a dose-dependent(1-25 μmol phospholipidkg-1) and a time-dependent mannar in beagles.

作者: Xuling Wang Chunling Wang Yuqing Su Qingjing Tian Boqun Li Jingjing Quan Yanzhi Song Xinrong Liu Yihui Deng

作者单位: School of Pharmacy, Shenyang Pharmaceutical University, No.103, Wenhua Road, Shenyang,Liaoning, 1100 Beijing Chengyuanjiaxin Pharmaceutical Technology Co.Ltd., No.160, West Fourth Ring Road,Haidian Dis

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 298-300

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）