Effect of stabilizers on the in vitro and in vivo performances of spironolactone nanoparticles

摘要：

　　To investigate the effects of stabilizers on the in vitro and in vivo performances of nanoparticles (NPs), four types of spironolactone (SPN)NPs with similar diameters but different stabilizers were prepared.All the formulations were in the same crystalline, however, the in vitro dissolution profiles as well as the in vivo pharmacokinetics performances were different.

作者: Simeng Mu Qiang Fu Mo Li Mengran Guo Wenqian Yang Yongjun Wang Zhonggui He

作者单位: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China Country Liaoning Institute for Drug Control, Shenyang, Liaoning, 110036,China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 306-308

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）