Dual imaging-guided photothermal/chemotherapeutic therapy using liposomes

摘要：

　　In this work, We synthesized a novel multifunctional nano liposome drug delivery system, the photothermal sensitive liposomes (PTSL), with doxorubicin (DOX) wrapped in the hydropholic layer and cypate dopped in the hydrophobic layer as the theranostic agents.A series of in vivo and in vitro characterization studies showed that the synthesized PTSL is stable, with DL % of 9± 1.5 and EE % of 82.7 ±2.1.And the in vivo and in vitro studies further showed that the liposomes we synthesized above can achieved the functions of target-delivery, enhanced photochemical internalized release, chemotherapy and thremal therapy, indicating that the PTSL is a kind of promising drug delivery system for tumor diagnosis and targeting therapy.

作者: Zhihao Han Liwei Lv Yueqing Gu

作者单位: School of Engineering China Pharmaceutical University, Nanjing, Jiangsu, 210009, China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 309-310

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）