Influence of Drug Physicochemical Properties on Drug solubility and Release in Hydroxy Pressure Sensitive Adhesives

摘要：

　　The relationship between drug physicochemical properties and drug release behavior was conducted with liner regression in transdermal patch.In low drug loading (0.25%) drug release rate was linear related with polar surface area of drug, In the high drug loading (2%) drug release percentage was dependent on the drug polarizability value and log P.Combining the results of FT-IR and drug miscibility studies, it was confirmed that drug-PSA interactions was appeared in hydrogen bond and the interaction ability was limited by the hydroxyl functional groups quantity, which means that PSA functional groups can be saturated by models drug when the drug loading was high enough.

作者: Chao Liu Liang Fang

作者单位: Department of Pharmaceutical Sciences, Shenyang Pharmaceutical University, 103 Wenhua Road,Shenyang, Liaoning, 110016, China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 311-312

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）