Paclitaxel-Prodrug Self-assembly Nanoparticles for Bimodal Imaging Guided Combination Cancer Therapy
Recently, nanomedicine without drug carriers draws much more attentions of many pharmacists.In this study, a novel di-payload paclitaxel conjugate with high drug loading (~78%) was developed by conjugating PTX to PTX via pH-sensitive carbonate linkage and disulfide linkage (PTX-S-S-PTX).The PTX prodrug was able to self-assemble into uniform nanoparticle with mean diameter of 123.7±2.597am.In addition, we prepared a self-assembled nanoparticle with the NIR probe 1, 1-dioctadecyl-3, 3, 3, 3-tetramethylindotricarbocyanine iodide (DiR)encapsulated within the cores for photothermal therapy (PTT) and chemotherapy applications.The DiR-loaded self-assembled nanoparticles (DSN)were featured with advantages including high drug loading, stealth-like pharmacokinetics, efficient tumor passive uptake, and the capabilities to simultaneously load with imaging or therapeutic agents.
Xiangfei Han Yongjun Wang
School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016,China
国际会议
沈阳
英文
315-316
2016-04-28（万方平台首次上网日期，不代表论文的发表时间）