Preparation and characterization of polymeric micelles for anticancer drug 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol

摘要：

　　Nanoscale polymeric micelles have promising applications as drug delivery systems.In this work, to increase the water solubility,sustain the releasing rate and improve the tumor targeted delivery of 25-OCH3-PPD, we developed biodegradable poly(ethylene glycol)-poly(lactic-co-glycolic acid) (MPEG-PLGA) micelles entrapping 25-OCH3-PPD.The prepared 25-OCH3-PPD micelles have a mean particle size of 136.0 ± 2.30 nm, and release 25-OCH3-PPD in a controlled fashion.25-OCH3-PPD and 25-OCH3-PPD micelles inhibited A549 tumor cell growth in vitro.Polymeric micelles reported in this study may be promising for targeted 25-OCH3-PPD delivery.

作者: Caihong Shi Yuanzeng Min Kai Shi Yue Ma Yuqing Zhao Andrew Z.Wang

作者单位: School of Functional Food and Wine, Shenyang Pharmaceutical University, 103 Wenhua Road,Shenyang 110 Laboratory of Nano-and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Cent School of Pharmacy, Shenyang Pharmaceutical University, Wen Hua Road, No.103, Shenyang 110016, Liaon School of Functional Food and Wine, Shenyang Pharmaceutical University, 103 Wenhua Road,Shenyang 110

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 334-335

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）