In Vitro Reversal Mutidrug Resistance Effect Of Docetaxel-loaded Cholesterol-Coupled TPGS Micelles

摘要：

　　TPGS(D-α-Tocopheryl polyethylene glycol succinate) has an extremely prominent effect on reversing multidrug resistance (MDR) of tumor.However, its high CMC value leads to poor dilution stability.Given this shortcoming, CHM (cholesterol chloroformate) was grafted on TPGS,named as TPGS-CHMC.The derivatives were used to prepare micelles.We chose Docetaxel (DTX) as the model drug and human ovarian cancer A2780/T cells as the model cells to investigate the antitumor efficacy, reversal MDR effect as well as advantages of TPGS-CHMC/DTX micelles by MTT assay, apoptosis assay and cell cycle assay.

作者: Mengyang Liu Liang Li Lei Shang Bo Peng Ling Hu Yihui Deng Yanzhi Song

作者单位: Shenyang Pharmaceutical University, Shenyang 110016, China China Medical University, Shenyang,110001, China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 341-343

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）